Mouse A9 Cells* | CHO-D3 Cells† | |||||||
---|---|---|---|---|---|---|---|---|
Agonism | Antagonism | Agonism | Antagonism | |||||
Emax | pEC50 | AAmax | pKb | Emax | pEC50 | AAmax | pKb | |
Dopamine | 159 ± 16 | 6.95 ± 0.08 | N.T. | N.T. | 102 ± 1 | 7.73 ± 0.01 | N.T. | N.T. |
Pramipexole | 130 ± 17 | 7.30 ± 0.11 | N.T. | N.T. | 106 ± 3 | 8.65 ± 0.07 | N.T. | N.T. |
7-OH-DPAT | 145 ± 9 | 7.69 ± 0.17 | N.T. | N.T. | 105 ± 4 | 8.50 ± 0.09 | N.T. | N.T. |
Quinpirole | 100 ± 3 | 7.01 ± 0.07 | N.T. | N.T. | 101 ± 2 | 8.80 ± 0.02 | N.T. | N.T. |
Cariprazine | 30 ± 3 | 8.50 ± 0.32 | 81 ± 3 | 9.22 ± 0.18 | 71 ± 4 | 8.58 ± 0.30 | 27 ± 2 | 9.57 ± 0.28 |
Aripiprazole | 34 ± 7 | 7.66 ± 0.35 | 84 ± 4 | 8.52 ± 0.12 | 69 ± 2 | 7.53 ± 0.06 | 24 ± 3 | 7.80 ± 0.01 |
Haloperidol | N.T. | N.T. | 108 ± 4 | 10.47 ± 0.28 | N.T. | N.T. | 110 ± 4 | 8.15 ± 0.03 |
SB-277011 | N.T. | N.T. | N.T. | N.T. | N.T. | N.T. | 52 ± 6 | 7.56 ± 0.08 |
AAmax, percentage maximal antagonism achieved against (±)quinpirole in mouse A9 cells and maximal reversal of 100 nM 7-OH-DPAT-induced inhibition of 10 μM forskolin-induced cAMP accumulation in CHO-D3 cells, respectively. Shown are the means ± S.E.M. from three to six independent experiments in duplicate or triplicate. N.T., not tested.
↵* In these experiments (±)-quinpirole was used. Emax represents maximal stimulation relative to 1 μM (±)-quinpirole.
↵† In these experiments (+)quinpirole was used. Emax represents the maximal inhibition of 10 μM forskolin-induced cAMP accumulation.