TABLE 2

Noncompartmental pharmacokinetic parameters for free PF-04840082 concentrations in Sprague-Dawley rats after intravenous administration of PF-04840082

Values are reported as mean ± S.D.

DoseAUC0–168 hCmaxCaverageaCminb
mg/kgμg · hr/mlμg/mlμg/mlμg/ml
0.121.2 ± 2.21.81 ± 0.160.127 ± 0.013<LLOQ
1850 ± 88.824.6 ± 1.65.06 ± 0.5280.205 ± 0.172
1013,300 ± 1000252 ± 29.779.0 ± 5.9438.7 ± 8.50
100141,000 ± 18,7002660 ± 313841 ± 110439 ± 116

  • ↵a Caverage = AUC0-inf /tlast of first dosing interval (not for the entire duration of study because of sparse sampling).

  • ↵b Cmin = first dosing interval (0–168 h).