Agonist | | | |
Histamine | 99 ± 17 (100) (1) | 1.7 −10a,b,c (100) (1) | Agonist |
Histidine | No effect at 100 | No effect at 100c | Not active |
4-Methylimidazole | 93 ± 10 (106) (1) | Not tested | Not active |
pros-Methylhistamine | No effect at 100 | No effect at 10c | Not active |
tele-Methylhistamine | 97 ± 22 (102) (1) | 7.2 ± 1.5 (122) (1) | Not active |
Nα-Methylhistamine | No effect at 100 | No effect at 10c | Agonist |
Nα,Nα-Dimethylhistamine | No effect at 100 | Not tested | Agonist |
(R)-α-Methylhistamine | 41 ± 24 (241) (0.3) | EC50 ≈ 10c (100) | H3-Agonist |
Burimamide | 6 ± 2 (1650) (0.4) | Not tested | H2/H3-Antagonist |
2-Pyridylethylamine | 5 ± 0.5 (1980) (1) | Not tested | H1-Agonist |
Antagonist/inverse agonist | | | |
Impromidine | 15 ± 3 | ≈10b | H2-Agonist/H3-antagonist |
Imetit | Inhibitory effect at 100 | Inhibitory effect at 10c | H3-Agonist |
Thioperamide | No effect at 2 | No effect at 10b | H3-Antagonist |