TABLE 2

Hepatic mitochondrial GPx activity in naive or alcohol-treated WT, MnSOD⁺⁺⁺, and MnSOD^+/− mice

Mice killed 2 or 24 h after the intragastric administration of water served as pooled zero-time controls (0 h) for the alcohol treatment. Other mice were killed 2 or 24 h after the intragastric administration of alcohol (5 g/kg). Results are means ± S.E.M. for 5 to 10 mice. Two-way ANOVA indicated an effect of genotype and alcohol treatment time.

Mice	GPx Activity
Mice	0 h	2 h	24 h
	nmol/min/mg protein
WT	205 ± 7	152 ± 9^#	134 ± 9^#
MnSOD⁺⁺⁺	211 ± 12	182 ± 9*	185 ± 12*
MnSOD^+/−	174 ± 5*	123 ± 14^#	132 ± 14^#

↵# Different from untreated mice (0 h) of the same genotype, P < 0.05.
↵* Different from WT mice studied at the same treatment time (0, 2, or 24 h), P < 0.05.