Cell cycle analysis of the cells treated by PD173074
All the data are expressed as mean ± S.D. in triplicate.
| Cell Line | PD173074 Treatment | Cycle Phase | ||
|---|---|---|---|---|
| G0/G1 | S | G2/M | ||
| nM | % | |||
| UM-UC-14 | Untreated | 54.2 ± 2.3 | 19.2 ± 0.7 | 26.2 ± 2.8 |
| 5 | 58.0 ± 2.1 | 15.0 ± 1.0 | 27.0 ± 2.7 | |
| 25 | 64.5 ± 2.3* | 9.2 ± 0.9* | 26.3 ± 2.4 | |
| 100 | 69.9 ± 1.8* | 2.9 ± 0.7* | 27.2 ± 2.1 | |
| MGHU3 | Untreated | 64.7 ± 2.3 | 10.0 ± 0.8 | 25.4 ± 1.1 |
| 5 | 65.3 ± 1.1 | 10.7 ± 0.6 | 24.0 ± 1.7 | |
| 25 | 71.3 ± 2.3* | 7.4 ± 1.1* | 21.3 ± 1.0 | |
| 100 | 72.8 ± 0.3* | 3.7 ± 0.7* | 23.5 ± 0.7 | |
| KU7 | Untreated | 62.6 ± 1.3 | 20.7 ± 1.4 | 16.7 ± 1.1 |
| 5 | 60.9 ± 1.1 | 20.4 ± 0.6 | 18.7 ± 1.5 | |
| 25 | 62.0 ± 0.5 | 21.7 ± 0.6 | 16.3 ± 0.5 | |
| 100 | 62.1 ± 0.8 | 22.8 ± 0.7 | 15.1 ± 1.5 | |
↵* Indicates statistically significant difference relative to the untreated.