TABLE 1

Animal data at 50 weeks of age

	LETO + Vehicle	OLETF + Vehicle	OLETF + Telmisartan	OLETF + Eplerenone	OLETF + Telmisartan + Eplerenone	OLETF + Hydralazine
No.	10	12	12	12	12	12
BW (g)	500 ± 15	629 ± 25*	602 ± 28*	608 ± 23*	611 ± 21*	605 ± 29*
Right KW (g)	1.31 ± 0.03	2.45 ± 0.13*	1.92 ± 0.11*^†	1.96 ± 0.15*^†	1.86 ± 0.09*^†	2.28 ± 0.21*
Right KW/BW ratio (%)	0.27 ± 0.02	0.38 ± 0.04*	0.32 ± 0.03*	0.32 ± 0.04*	0.29 ± 0.04	0.35 ± 0.06*
PPBG (mg/dl)	6 ± 2	14 ± 3*	13 ± 2*	13 ± 4*	13 ± 3*	14 ± 4*
Plasma sodium (mEq/l)	144 ± 5	145 ± 8	143 ± 6	142 ± 5	141 ± 6	144 ± 8
Plasma potassium (mEq/l)	4.2 ± 0.3	4.4 ± 0.3	4.8 ± 0.5	4.9 ± 0.4	4.9 ± 0.6	4.8 ± 0.6
Plasma Cr (mg/dl)	0.39 ± 0.03	0.41 ± 0.05	0.41 ± 0.04	0.40 ± 0.03	0.39 ± 0.05	0.43 ± 0.06
Plasma aldosterone (pg/ml)	281 ± 44	368 ± 61	216 ± 49^†	873 ± 102*^†	726 ± 74*^†	383 ± 48

BW, body weight; KW, kidney weight.
↵* P < 0.05 vs. LETO + vehicle.
↵† P < 0.05; OLETF + vehicle vs. OLETF + telmisartan, eplerenone, or telmisartan + eplerenone.