Epicardial arteries
| Prehypertensive and Antihypertensive Treatment | |||||
|---|---|---|---|---|---|
| No Pretreatment | Transient Pretreatment (5 mg/kg/day) | ||||
| Vehicle | 5 mg/kg/day Candesartan | Vehicle | 1.5 mg/kg/day Candesartan | 5 mg/kg/day Candesartan | |
| Lumen diameter (μm) | 57.7 ± 19.8 | 57.7 ± 19.5 | 53.5 ± 13.8 | 59.2 ± 24.0 | 73.3 ± 11.2* |
| Media thickness (μm) | 42.3 ± 9.4 | 33.9 ± 4.9* | 27.3 ± 3.1* | 29.5 ± 6.8* | 30.1 ± 4.2* |
| Cross-sectional area (μm2) | 4347 ± 1967 | 2336 ± 1000 | 2505 ± 519 | 2347 ± 1094 | 2423 ± 1109 |
| W/liter | 0.59 ± 0.04 | 0.55 ± 0.09 | 0.54 ± 0.14 | 0.48 ± 0.14 | 0.37 ± 0.07* |
| Cells/lumen | 0.38 ± 0.05 | 0.32 ± 0.11 | 0.36 ± 0.16 | 0.28 ± 0.13 | 0.28 ± 0.05* |
↵* P < 0.05 vs. placebo/placebo.