TABLE 2

Peptide half-life values in the different matrixes

MatrixHalf-life
IaIbIIaIIb
min [95% CI]
Plasma50.0 [48.9, 51.2]72.5 [69.4, 75.8]29.6 [28.0, 31.1]97.7 [90.9, 105.6]
Liver323.1 [256.5, 436.4]355.9 [282.5, 478.2]112.6 [96.8, 134.6]105.7 [92.8, 122.7]
Kidney72.7 [66.4, 80.2]78.1 [76.5, 79.6]54.9 [48.2, 63.8]54.9 [52.9, 57.1]
Brain178.3 [135.5, 260.8]268.0 [218.6, 346.4]258.2 [214.2, 325.0]276.5 [252.4, 305.7]
Stomach6.3 [5.7, 7.1]4.2 [2.7, 9.6]20.3 [17.0, 25.0]10.0 [6.7, 19.2]
Duodenum6.4 [5.5, 7.7]4.2 [3.1, 6.8]11.0 [9.2, 13.6]6.1 [4.0, 12.7]
  • CI, confidence interval.