Table 1

An example of the creation of 16 matched pairs of one representative striatal neuron's firing during three experimental periods (predrug, cocaine, recovery/reversal) in the medium cocaine dose (10 mg/kg) group using statistical blocking

Left half of table represents a 2D slice of the 3D head movement-blocking matrix (see text) comprising 10 levels of distance and 10 levels of duration at one level of apex (220 mm < apex ≤ 225 mm) for one representative animal at each of the three periods. Each categorical level was labeled by the maximum of the range of parameter values assigned to it, e.g., a distance level of 21 had a range of (15 mm < distance ≤ 21 mm). Right half shows the firing rates associated with all the blocking matrix cells in the left half that contained enough movements (n ≥ 5) to create a matched pair. The bolded and underlined entries constitute an example of a particular set of cells (distance = 21 mm, duration = 100 ms, apex = 225 mm) in the 3D blocking matrix that yield a matched pair for the T1–T2 analysis of the effects of cocaine on firing rate (T1FR = 2.4 discharges/s, T2FR = 3.1 discharges/s) and another matched pair for the T1–T3 analysis of recovery/reversal (T1FR = 2.4 discharges/s, T3FR = 1.1 discharges/s).

Time PeriodHead Movement DurationNumber of Head MovementsHead Movement DurationMean Firing Rate (discharges/s)
Head Movement Distance (mm)Head Movement Distance (mm)
9152127333945515758+9152127333945515758+
msms
T1338330.0
Predrug67251766670.03.37.70.0
1001020101002.40.00.0
1339201213161331.00.00.00.00.0
167571670.3
200322000.3
233362330.9
267267
300300
301+301+
T2335330.0
Cocaine6727201618673.06.20.01.1
100121451003.111.90.0
1335881181333.01.03.34.61.0
167101671.3
200112003.3
23352330.0
267267
300300
301+301+
T33313330.0
Recovery/Reversal6754381316670.81.40.02.6
1003133121001.10.30.0
13313121517561330.000.00.50.3
1671091670.1
200702000.1
233452330.2
267267
300300
301+301+