Table 1

Characterization measures for the Mg2+-free and 4-AP (100 μM) aCSF-induced LFP epileptiform activity in the CA1, CA3, and DG regions of the hippocampus

LFP peak burst amplitude values are presented as a minimum and maximum range and mean ± S.E.M. LFP burst duration and frequencies are presented as mean ± S.E.M. A minimum of six separate hippocampal slices were used in the characterisation of each in vitro model.

In Vitro ModelHippocampal RegionLFP Peak Burst AmplitudeLFP Burst DurationLFP Burst Frequency
MinimumMaximumMean ± S.E.M.
μVmsHz
Mg2+-freeCA1 (n = 15)77438257 ± 30747 ± 290.31 ± 0.01
CA3 (n = 12)37971303 ± 88722 ± 310.30 ± 0.02
DG (n = 15)66781275 ± 53715 ± 280.30 ± 0.02
4-AP (100 μM)CA1 (n = 15)54383201 ± 26508 ± 210.77 ± 0.08
CA3 (n = 13)131218364 ± 101524 ± 190.71 ± 0.07
DG (n = 18)44674338 ± 44552 ± 120.75 ± 0.06