Summary of the plasma pharmacokinetic parameters of MLN3897 for treatments with and without fluconazole
Data are mean ± S.D.
| Pharmacokinetic Parameter | MLN3897 + Fluconazole | MLN3897 | Fold Change |
|---|---|---|---|
| AUC0–24 (ng·h/ml) | 327.3 ± 115.3 | 83.3 ± 35.2 | 3.93 |
| Tmax (h) | 8.00 | 6.55 | 1.22 |
| Cmaxss (ng/ml) | 16.3 ± 6.1 | 4.64 ± 1.97 | 3.51 |
| Cminss (ng/ml) | 11.0 ± 4.2 | 2.21 ± 1.02 | 4.98 |