Survival of rats bearing advanced intracranial 9L tumors
| Treatment Groups | Rats per Group | MLSa (Range) | %ILSb | pc | Days to Volume Thresholdd |
|---|---|---|---|---|---|
| Control (saline) | 15 | 22 (20–24) | N/A | 21 | |
| Cre-PAC 50 mg/kg ×1 | 3 | 23 (22–23) | 5 | 0.65 | 21 |
| Cre-PAC 40 mg/kg ×2 | 4 | 24 (22–25) | 9 | 0.12 | 22.7 |
| Cre-PAC 20 mg/kg ×3 | 4 | 20 (18–24) | −9 | 0.15 | 26 |
| L-PAC 50 mg/kg ×1 | 4 | 25 (21–26) | 14 | 0.10 | 21 |
| L-PAC 40 mg/kg ×2 | 9e | 27.8 (27–28) | 26 | <0.0002 | 26 |
| L-PAC 20 mg/kg ×3 | 11e | 30.8 (24–32) | 40 | <0.0001 | 31.4 |
N/A, not applicable.
↵a Median lifespan.
↵b Percentage increase in lifespan: (mlstreated − MLScontrol)/MLScontrol.
↵c Two-tailed p value from nonparametric Mann-Whitney test compared with control group.
↵d Extrapolation of tumor growth rate to lethal volume of 400 mm3.
↵e Average of two experiments. Median lifespan did not differ significantly in the two experiments.