Effects of cucurbitacin R on TNF-α, IL-1β, and IL-4 in DTH induced by oxazolone
| DTH Induced by Oxazolone | ||||||
|---|---|---|---|---|---|---|
| TNF-α | IL-1β | IL-4 | ||||
| pg/ml ± S.E.M. | %I | pg/ml ± S.E.M. | %I | pg/ml ± S.E.M. | %I | |
| Blank | 211 ± 36 | 32 ± 8 | 32 ± 8 | |||
| Control | 677 ± 82 | 212 ± 39 | 207 ± 40 | |||
| Cucurbitacin R | 471 ± 73† | 44 | 114 ± 18† | 55 | 116 ± 15* | 52 |
| Dexamethasone | 162 ± 19* | 110 | 30 ± 10* | 101 | 30 ± 10* | 111 |
↵ Percentages of inhibition were calculated from values of test compounds minus blank (protein extract of animals treated with vehicle) versus control (protein extract of animals treated with DTH reagent) minus blank. Values are expressed as picograms of each cytokine production per milliliter ± S.E.M. Statistically significant difference with respect to the control is expressed as * P < 0.01 and † P < 0.05 (Dunnett's t test).