Table 3

Effect of drug treatment on arterial-venous (AV) gradient

Control+l-NMMA+l-NMMA + ISDN+l-NMMA + Sildenafil
Venous-arterial glucose difference (mg/dl)
    Baseline−3.6 ± 0.9−5.9 ± 0.7−5.2 ± 1.9−4.2 ± 0.8
    Bradykinin (200 ng/min)−3.1 ± 1.0−1.7 ± 1.0*−0.2 ± 2.4*−1.8 ± 0.7*
Venous-arterial t-PA difference (ng/ml)
    Baseline0.1 ± 0.20.5 ± 0.2†−0.4 ± 0.50.4 ± 0.4
    Bradykinin (200 ng/min)3.0 ± 0.5***6.3 ± 1.0***†††7.6 ± 1.4***††5.3 ± 1.7**

  • ↵* P < 0.05,

  • ↵** P < 0.01,

  • ↵*** P < 0.001 versus baseline.

  • ↵† P < 0.05,

  • ↵†† P < 0.01,

  • ↵††† P < 0.001 versus control.