Plasma and brain PK parameters of nelotanserin in rat
Results after a single oral dose of 10 mg/kg.
| Parameter | Plasma | Brain | Brain/Plasma |
|---|---|---|---|
| t½ (h) | 21.6 | 4.6 | |
| tmax (h) | 4.0 | 4.0 | |
| Cmax (μg/ml) | 0.928 | 0.357 | 0.385 |
| tlast (h) | 40.0 | 8.0 | |
| AUClast (h·μg/ml) | 8.327 | 1.802 | |
| AUC0-inf (h·μg/ml) | 8.386 | 3.091 | 0.369 |
| MRTlast (h) | 5.6 | 4.4 | |
| AUC0–8 h (h·μg/ml) | 5.478 | 1.802 | 0.329 |