Table 2
Plasma and brain PK parameters of nelotanserin in rat
Results after a single oral dose of 10 mg/kg.
Parameter
Plasma
Brain
Brain/Plasma
t
½
(h)
21.6
4.6
t
max
(h)
4.0
4.0
C
max
(μg/ml)
0.928
0.357
0.385
t
last
(h)
40.0
8.0
AUC
last
(h·μg/ml)
8.327
1.802
AUC
0-inf
(h·μg/ml)
8.386
3.091
0.369
MRT
last
(h)
5.6
4.4
AUC
0–8 h
(h·μg/ml)
5.478
1.802
0.329