Comparison of the effects of α7- and α4β2-selective compounds on body mass, food intake, and plasma parameters
| Parameter | Control | TC-7020 | Control | Compound A (α4β2) |
|---|---|---|---|---|
| Food intake (g/day) | 6.1 ± 0.5 | 3.9 ± 0.4* | 6.0 ± 0.9 | 2.9 ± 0.6* |
| Body mass (g) | 65 ± 9 | 45 ± 7* | 55 ± 9 | 44 ± 6* |
| Blood glucose (mg/dl) | 401 ± 11 | 268 ± 14* | 344 ± 19 | 284 ± 15 |
| Plasma triglycerides (mg/dl) | 380 ± 50 | 140 ± 25* | 388 ± 21 | 411 ± 12 |
| TNF-α (pg/ml) | 42 ± 5 | 19 ± 2* | 43 ± 6 | 52 ± 2 |
Obese (db−) mice were administered vehicle (control), TC-7020 (1 mg/kg), or Compound A (3 mg/kg) once daily by oral gavage for 14 days. Results represent the mean ± S.E.M. (n = 8;
↵* p < 0.05).