Comparison of pEC50 and Rmax values for arecoline-stimulated [3H]IPx accumulation in CHO-M1 cells after a 24-h pretreatment with oxo-M, AC-42, pilocarpine, or vehicle
CHO-M1 cells were treated as described in the legend to Fig. 7. pEC50 values are shown as −log M values, and Rmax values are given as a percentage of the maximal response to arecoline in vehicle-treated control cells.
| 24-h Pretreatment | pEC50 | Rmax |
|---|---|---|
| KHB | 5.44 ± 0.07 | 100 |
| oxo-M (15 μM) | 4.89 ± 0.05 ** | 32 ± 2 ** |
| AC-42 (10 μM) | 5.07 ± 0.07 * | 107 ± 9 |
| Pilocarpine (35 μM) | 5.10 ± 0.06 * | 56 ± 14 |
↵Data are presented as means ± S.E.M. for three separate experiments performed in duplicate. Statistically significant differences between drug treatments and vehicle-treated control cells are shown as *, P< 0.05; **, P < 0.01.