Pharmacokinetic parameters of transplacental passage of Rho123 and GLB
Pharmacokinetic parameters were obtained by fitting experimental data with eqs. 4 and 5 for fm and mf transport, respectively. Data are presented as mean ± S.D.
| Rho123 | GLB | |||
|---|---|---|---|---|
| Fetal-to-Maternal Transport | Maternal-to-Fetal Transport | Fetal-to-Maternal Transport | Maternal-to-Fetal Transport | |
| Clpd (ml/min/g) | 0.125 ± 0.022 | 0.129 ± 0.015 | 0.294 ± 0.058 | 0.304 ± 0.043 |
| Vmax (mmol/min/g) | 0.97 ± 0.12 | 6.56 ± 0.47 | 45.8 ± 5.84 | 2.53 ± 0.24 |
| Km (μM) | 1.42 ± 0.19 | 88.0 ± 16.8 | 88.5 ± 11.6 | 11.2 ± 1.41 |