Pretreatment Group | Probe DAMGO ED50 (95% CI) | Relative Potency (95% CI) (Compared with Saline) | Pretreatment Group | Probe DAMGO ED50 (95% CI) | Relative Potency (95% CI) (Compared with Saline Pretreatment) |
---|---|---|---|---|---|
pmol i.t. | pmol i.t. | ||||
Saline | 51 (34–75) | 1 | Saline | 52 (39–68) | 1 |
DAMGO (0.6 pmol) | Not calculable | Not calculable | Normal IgG + DAMGO (0.06 pmol) | 50 (32–77) | 0.9 (0.58–1.6) |
DAMGO (0.6 pmol) + agmatine (4 nmol) | 75 (39–140) | 1.5 (0.69–3.1) | Anti-AG IgG + DAMGO (0.06 pmol) | Not calculable | Not calculable |