Treatment | Quarter-Life (± S.E.M.) | |
---|---|---|
0.1 mg/kg/Injection Cocainea | Saline/DM CocEb | |
Saline substitution | 0.24 (0.02) | 0.10 (0.03)* |
0.032 mg DM CocE | 0.22 (0.03) | 0.18 (0.02) |
0.1 mg DM CocE | 0.20 (0.01) | 0.20 (0.01) |
0.32 mg DM CocE | 0.20 (0.01) | 0.33 (0.07) |
1.0 mg DM CocE | 0.23 (0.01) | 0.10 (0.02)*** |
↵a Mean QL value ± S.E.M. (n = 6) for responding maintained by 0.1 mg/kg/injection cocaine during session immediately preceding those in which the effects of CocE T172R/G173Q pretreatment, or saline substitution were assessed.
↵b Mean QL value ± S.E.M. (n = 6) for responding maintained by 0.1 mg/kg/injection cocaine during session in which rats were pretreated with CocE T172R/G173Q and allowed to respond for 0.1 mg/kg/injection cocaine, or when saline was available for injection.
↵* p < 0.05;
↵*** p < 0.001 represents a significant difference in QL value compared with the corresponding baseline sessions in which responding was reinforced by 0.1 mg/kg/injection cocaine