Table 5

BMS-066 inhibits NF-κB-dependent but not NF-κB-independent responses in B and T lymphocytes

Cell	Stimulation	Endpoint	IC₅₀
			μM
B cell, mouse splenic	α-IgM	IκBα phosphorylation	0.11 ± 0.05
B cell, human tonsillar	α-IgM + IL-4	Proliferation	0.34 ± 0.11
B cell, human tonsillar	α-CD40 + IL-4	Proliferation	0.28 ± 0.11
B cell, human tonsillar	α-IgM + IL-4	IgM Production	7 ± 1
B cell, human tonsillar	α-IgM + IL-4	IgG Production	0.29 ± 0.06
Jurkat T cell^a	α-CD3	NF-κB-dependent gene expression^a	0.49 ± 0.09
Jurkat T cell^b	α-CD3	NFAT-dependent gene expression^b	>40
T cell, human peripheral blood	α-CD3	Proliferation	0.26 ± 0.09
T cell, human peripheral blood	α-CD3	IL-2	0.12 ± 0.07
T cell, human peripheral blood	α-CD3	IL-17	0.37 ± 0.10
T cell, human peripheral blood	α-CD3	IL-1β	0.49 ± 0.09

↵^a Jurkat T cells with a stable integration of luciferase under the control of an NF-κB-dependent promoter.
↵^b Jurkat T cells with a stable integration of luciferase under the control of an NFAT-dependent promoter.