Summary of mean pharmacokinetic parameters for BMS-066
BMS-066 was administered by oral or intravenous routes (see Materials and Methods for details). FPO is defined as the oral bioavailability, Cmax (p.o.) is the maximum concentration achieved after peroral administration, Tmax (p.o.) is the time after administration that the Cmax is obtained, and VSS is the apparent steady-state volume of distribution.
| Parameters | ||||||
|---|---|---|---|---|---|---|
| Intravenous Half-Life | VSS | Total Clearance | FPO | Cmax (p.o.) | Tmax (p.o.) | |
| h | liters/kg | ml · min−1 · kg−1 | % | μM | h | |
| Rat (Lewis) | 3.7 ± 0.8 | 0.5 ± 0.1 | 4.5 ± 0.5 | 90 | 17.6 ± 9.8a | 1 |
| Mouse (BALB/c) | 0.66 ± 0.08 | 1.8 ± 0.6 | 52 ± 18 | 79 | 1.6 ± 0.5b | 0.25 |
| Dog | 3.3 ± 0.1 | 0.6 ± 0.1 | 3.1 ± 0.4 | 72 | 10.3 ± 2.5c | 1 |