D50 values for development and expression of morphine tolerance
| Morphine Tolerance | D50 | CI | No. of Subjects |
|---|---|---|---|
| Development | |||
| Sal/Sal | 4.6 | 3.3–5.9 | 9 |
| U0126/Sal | 4.2 | 3.4–5.0 | 10 |
| Sal/MOR | 5.8 | 4.8–6.8 | 10 |
| U0126/MOR | 9.4 | 8.3–10.5 | 14 |
| Expression | |||
| Saline | 6.0 | 2.2–9.8 | 8 |
| U0126 | 10.8 | 6.2–15.3 | 8 |