Mean plasma concentrations of APD791, AR295980, AR295981, and total (APD791 and active metabolites) in male beagle dogs after oral dosing of APD791 at 1 mg/kg after acute or subchronic administration.
BLQ, below lower limit of quantitation (1 ng/ml).
↵ a APD791, M1, and M2 were converted to APD791·HCl equivalents.
↵ b Total: sum of the plasma concentrations of APD791, M1, and M2 (nanogram equivalents of APD791·HCl).
↵ c Mean ± S.D.; n = 1–7.