TABLE 4

Plasma concentrations of APD791, AR295980, AR295981, and total (APD791 and active metabolites) in male beagle dogs after oral administration of APD791 at 10 mg/kg

Time	Plasma Concentration
Time	APD791^a	APD791-M1^a	APD791-M2^a	Total^b
		ng/ml
1 h	1500 ± 291^c	400 ± 124	10.8 ± 4.7	1910 ± 292
6 h	29.5 ± 14.6	125 ± 53	7.83 ± 5.48	161 ± 49.1
12 h	BLQ	31.9 ± 8.7	2.30 ± 0.74	34.2 ± 9.2
24 h	BLQ	5.63 ± 1.07	1.52	6.01 ± 1.78

BLQ, below lower limit of quantitation (1 ng/ml).
↵ ^a APD791, M1 and M2 were converted to APD791·HCl equivalents.
↵ ^b Total: sum of the plasma concentrations of APD791, M1 and M2 (ng equivalents of APD791·HCl).
↵ ^c Mean ± S.D., n = 4.