TABLE 3

Pharmacokinetic parameters for APD791 and its metabolites, and the sum of APD791 and its metabolites after oral administration of APD791 at 10 mg/kg in male beagle dogs

Parameter	APD791^a	APD791-M1^b	APD791-M2^b	Total^c
t_1/2(h)	0.94 ± 0.04	5.1	12.5	5.7
t_max(h)	0.3 ± 0.1	0.5	2.0	0.3
C_max (μg/ml)	2.28 ± 0.32	0.336	0.0154	2.45
AUC_0-inf (hr·μg/ml)	3.55 ± 0.77	2.21	0.272	5.84

↵ ^a Values were determined from individual animal plasma concentration (nanogram equivalents of APD791·HCl) versus time profiles (mean ± S.D., n = 3).
↵ ^b Values were determined from pooled plasma concentration (nanogram equivalents of APD791·HCl) versus time profiles.
↵ ^c Values were determined from the sum of the plasma concentrations of APD791, M1, and M2 (nanogram equivalents of APD791·HCl) versus time profiles.