Ent1 | Dose | Plasma AUC0–30 min | Erythrocyte AUC0–30 min | Blood AUC0–30 min | Plasma Cmax/D | Erythrocyte Cmax/D | Blood Cmax/D | Plasma Tmax | Erythrocyte Tmax |
---|---|---|---|---|---|---|---|---|---|
mg/kg | μ g min/ml | μ g/ml/mg/kg | min | ||||||
+/+ | 0.024 | 0.150 ± 0.035 | 0.281 ± 0.029 | 0.220 ± 0.029 | 0.252 ± 0.047 | 0.494 ± 0.072 | 0.372 ± 0.033 | 11.7 ± 5.8 | 65.0 ± 52.7 |
0.244 | 0.800 ± 0.360 | 1.49 ± 0.611 | 1.2 ± 0.50 | 0.107† ± 0.016 | 0.249† ± 0.052 | 0.174† ± 0.028 | 11.7 ± 5.8 | 60.0 ± 0.0 | |
6.1 | 9.39 ± 1.67 | 20.8 ± 2.1 | 16.0 ± 1.6 | 0.075† ± 0.018 | 0.181† ± 0.029 | 0.134† ± 0.015 | 30.0 ± 26.0 | 50.0 ± 17.3 | |
−/− | 0.024 | 0.055* ± 0.026 (2.72 ↓) | 0.061* ± 0.015 (4.63 ↓) | 0.059* ± 0.015 (3.71 ↓) | 0.096* ± 0.041 (2.63 ↓) | 0.128* ± 0.046 (3.88 ↓) | 0.105* ± 0.031 (3.53 ↓) | 26.7 ± 29.3 | 50.0 ± 17.3 |
0.244 | 0.499 ± 0.139 (1.60 ↓) | 0.307* ± 0.061 (4.87 ↓) | 0.386* ± 0.093 (3.13 ↓) | 0.093 ± 0.017 (1.15 ↓) | 0.068* ± 0.003 (3.66 ↓) | 0.071* ± 0.013 (2.45 ↓) | 15.0 ± 0.0 | 60.0 ± 0.0 | |
6.1 | 11.7 ± 2.6 (1.25 ↑) | 5.44* ± 1.75 (3.82 ↓) | 8.27* ± 1.9 (1.93 ↓) | 0.102 ± 0.023 (1.35) | 0.054* ± 0.006 (3.36 ↓) | 0.068* ± 0.013 (1.96 ↓) | 20.0 ± 8.7 | 50.0 ± 17.3 |