TABLE 1
Structure and affinity (pKi) of a series of ligands at wild type and D116A mutant of the 5-HT1A receptor using [3H]8-OH-DPAT and [3H]WAY100,635 (in boldface) as radioligands
pKi values were determined as described under Materials and Methods and represent the −log (Ki), where Ki values are expressed in nanomolar for each compound. Ki ratios of D116A/wild type (WT) were calculated from the means of Ki values.