TABLE 1

Potency (pEC50) values generated from concentration-response curves from yeast signaling assays performed in strains expressing the adenosine A1 receptor with either Gpa1/Gα o, Gpa1/Gα i1/2, or Gpa1/Gαi3

Values represent the mean ± S.E. obtained from three to five experiments conducted in duplicate.

Yeast StrainR-PIAVCP-189
Gαo7.38 ± 0.18N.D.
Gαi1/28.41 ± 0.176.97 ± 0.01
Gαi38.08 ± 0.076.29 ± 0.25

  • N.D., not determined.