Effect of etanercept on SLD metabolism
Rats were killed and plasma was collected at 8 h after the second SLD administration. Metabolite concentrations were determined as described under Materials and Methods. n = 4–5.
| Treatment | Concentration in Plasma | ||
|---|---|---|---|
| SLD | SLD Sulfone | SLD Sulfide | |
| μg/ml | |||
| Veh/SLD/LPS | 59.6 ± 12.2 | 139.3 ± 16.7 | 62.2 ± 12.1 |
| Etan/SLD/LPS | 52.8 ± 10.8 | 153.8 ± 13.8 | 39.8 ± 13.3 |
Veh, vehicle; Etan, etanercept.