Total brain concentration versus time (AUC) of drugs and metabolites after injection (subcutaneous) of 5 and 15 μmol/kg heroin, 6MAM, and morphine Values are calculated as AUC from the curve for the mean values of each time point. The range is shown in parentheses [AUCmin (AUC − S.E.M.) − AUCmax (AUC + S.E.M.)], n = 4 to 8 mice.
| Injected Drug | AUC | |||
|---|---|---|---|---|
| Heroin | 6MAM | Morphine | M3G | |
| nmol/g × min | ||||
| Heroin, 5 μmol/kg | 0.05 (0.03–0.07) | 2.99 (2.76–3.22) | 0.84 (0.72–0.96) | N.D. |
| Heroin, 15 μmol/kg | 0.53 (0.41–0.65) | 17.68 (15.35–20.00) | 3.53 (2.92–4.14) | 0.051 (0.018–0.085) |
| 6MAM, 5 μmol/kg | 2.38 (2.07–2.69) | 0.73 (0.67–0.79) | N.D. | |
| 6MAM, 15 μmol/kg | 8.69 (7.32–10.06) | 1.92 (1.65–2.19) | 0.147 (0.062–0.232) | |
| Morphine, 5 μmol/kg | 0.56 (0.49–0.63) | N.D. | ||
| Morphine, 15 μmol/kg | 2.07 (1.88–2.25) | 0.22 (0.15–0.29) | ||
N.D., not determined.