TABLE 2

Echocardiographic analysis

Variables
Week
ND
SFD
AHAB (12 mg/kg/day)
Rofecoxib (18 mg/kg/day)
Mean
S.E.M.
n
 Mean
S.E.M.
n
 Mean
S.E.M.
n
 Mean
S.E.M.
n
CO (ml/min) 0 79.4 4.0 9 74.5 4.3 11 77.5 2.9 10 78.9 4.0 7
4 103.2 11.1 6 87.3 9.9 10 109.57*,## 9.0 10 63.0 8.1 5
SV (μl) 0 243.6 8.1 9 242.8 10.7 11 251.0 8.9 10 256.4 9.6 9
4 300.5 20.8 6 282.3 23.1 10 341.7*,# 15.3 10 272.5 32.4 7
EF (%) 0 60.3 1.3 9 62.7 1.5 11 60.2 1.0 10 61.1 0.7 9
4 56.6 1.9 7 56.6 1.2 10 57.5 1.6 10 56.1 2.7 7
LVDd (mm) 0 7.06 0.12 9 6.84 0.14 11 7.01 0.13 10 7.16 0.21 9
4 8.23*,# 0.22 6 7.41 0.21 10 7.92 0.15 10 7.33 0.36 7
LVDs (mm) 0 3.81 0.13 9 3.75 0.17 11 3.78 0.11 10 3.73 0.23 9
4 4.60**,## 0.30 6 3.62 0.18 10 4.249*,# 0.15 10 3.69 0.29 7
LVM/BW (mg/g) 0 2.55 0.08 9 2.42 0.08 11 2.48 0.06 10 2.52 0.07 9
4 2.41**,## 0.08 6 3.01 0.20 10 2.69 0.07 10 3.30 0.23 7
T/B 0 0.369 0.010 9 0.365 0.013 11 0.358 0.007 10 0.354 0.008 9
4
0.390*,##
0.017
6
0.474
0.029
10
0.39***,#
0.011
10
0.501
0.042
7

  • CO, cardiac output; SV, stroke volume; EF, ejection fraction; LVDd, left ventricular diameter in diastole; LVDs, left ventricular diameter in systole; LVM/BW, left ventricular mass to body weight ratio; T/B, average LV wall thickness divided by radius in diastole

  • ↵* , p < 0.05

  • ↵** , p < 0.01

  • ↵*** , p < 0.001 vs. SFD

  • ↵# , p < 0.05

  • ↵## , p < 0.01

  • ↵### ; p < 0.001 vs. rofecoxib