TABLE 1

Effects of systemic administration (SA) versus local administration (LA) of telenzepine and WAY-100635 on dopamine release in the medial prefrontal cortex induced by systemic administration of atypical antipsychotic drugs


Drugs

Doses

Cortical Dopamine Efflux Pretreatment

References
None
Telenzepine
WAY-100635
mg/kg
SA
   AC260584 10 I B B Li et al., 2007
   NDMC 20 I B B Li et al., 2005
   Clozapine 20 I B B Present data and Ichikawa et al., 2001
   Risperidone 1.0 I B B Present data and Ichikawa et al., 2001
   Olanzapine 10 I B B Present data and Ichikawa et al., 2001
LA
   AC260584 10 I B NB Present data
   NDMC 20 I B NB Present data
   Clozapine 10 I B B Present data
   Risperidone 1.0 I NB B Present data
   Olanzapine
10
I
NB
B
Present data
  • I, increase; B, blockade; NB, no blockade