Route | Form | Dose | n | Analyte | Cmax | Tmax | t1/2 | AUC(0-inf) | F a | |
---|---|---|---|---|---|---|---|---|---|---|
mg-Eq RB/kg | μg/ml | h | μg·h/ml | % | ||||||
p.o. | Suspension | 5 | 3 | R-Baclofen | 4.00 ± 0.43 | 0.3 ± 0.2 | 3.6 ± 0.4 | 19.0 ± 1.50 | 92 ± 7 | |
Prodrug | 0.42 ± 0.14 | 0.2 ± 0.0 | 0.6 ± 0.7 | 0.09 ± 0.05 | NA | |||||
p.o. | CR2 | 10 mgb | 4 | R-Baclofen | 0.09 ± 0.07 | 3.5 ± 1.9 | 5.0 ± 1.3 | 0.78 ± 0.53 | 46 ± 26 | |
p.o. | SR1 | 10 mgb | 4 | R-Baclofen | 0.10 ± 0.03 | 3.6 ± 2.8 | 5.9 ± 2.1 | 1.14 ± 0.24 | 68 ± 6 | |
p.o. | SR2 | 10 mgb | 4 | R-Baclofen | 0.23 ± 0.09 | 3.0 ± 1.2 | 3.3 ± 0.5 | 1.05 ± 0.30 | 62 ± 8 | |
p.o. | SR3 | 10 mgb | 4 | R-Baclofen | 0.04 ± 0.02 | 6.5 ± 7.7 | 5.0 ± 2.5 | 0.27 ± 0.15 | 27 ± 19 | |
i.c. | Suspension | 5 | 4 | R-Baclofen | 3.04 ± 0.95 | 1.3 ± 0.5 | 3.6 ± 0.7 | 16.0 ± 4.78 | 77 ± 23 | |
|
|
|
| Prodrug | 0.82 ± 0.40 | 0.2 ± 0.0 | 0.5 ± 0.2 | 0.48 ± 0.18 | NA |