Effect of H2S donors (Lawesson's reagent and NaHS), l-cysteine alone, or l-cysteine with PAG in ethanol-induced gastric microscopic damage Data shown are medians with minimal and maximal scores shown in parentheses. Kruskal-Wallis nonparametric test, followed by Dunn's test was used for multiple comparisons for histological assessment.
Experimental Group (n = 6) | Hemorrhagic Damage (Score 0–4) | Edema (Score 0–4) | Epithelial Cell Loss (Score 0–3) | Inflammatory Cells (Score 0–3) | Total (Score 0–14) |
|---|---|---|---|---|---|
| Saline | 0 | 0 | 0 | 0 | 0 |
| Ethanol | 3.5 (3–4) | 4 (3–4) | 3 (2–3) | 0 | 0.5 (8–11) |
| Ethanol + Lawesson's reagent (27 μmol · kg–1) | 1 (0–1)* | 1 (0–1)* | 0 (0–1)* | 0 | 2 (0–2)* |
| Ethanol + NaHS (150 μmol · kg–1) | 1 (0–2)* | 1 (1–0)* | 1 (1–2)* | 0 | 2 (1–2)* |
| Ethanol + l-cysteine (50 mg · kg–1) | 1 (0–3)* | 2 (1–2) | 1 (1–3) | 0 | 5 (2–7)* |
| Ethanol + l-cysteine + PAG (50 mg · kg–1) | 4 (3–4)# | 4 (2–4)# | 2 (2–3) | 0 | 10 (8–11)# |