Agents | n | Vasodilator Responses at Concentrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 μM | 3 μM | 10 μM | 30 μM | 100 μM | 1000 μM | |||||||
% | ||||||||||||
Nicotine | 9 | 0.7 ± 2.0 | 3.5 ± 1.8 | 32.5 ± 4.1 | 72.6 ± 4.6 | 82.3 ± 3.1 | N.D. | |||||
Dopamine metabolites | ||||||||||||
3-Methoxytyramine | 5 | 4.5 ± 1.4 | 8.1 ± 2.1 | 24.0 ± 1.0 | 49.3 ± 3.8 | 80.7 ± 2.1 | N.D. | |||||
Capsaicin + 3-methoxytyramine | 5 | 0.9 ± 1.5 | 5.9 ± 1.8 | 24.8 ± 5.3 | 49.6 ± 5.4 | 77.4 ± 4.4 | N.D. | |||||
3,4-Dihydroxyphenylacetic acid | 3 | 1.6 ± 2.3 | –1.6 ± 1.0 | –2.4 ± 2.0 | –3.1 ± 5.7 | –10.0 ± 2.5 | N.D. | |||||
Homovanillic acid | 3 | –3.1 ± 0.6 | –3.3 ± 0.7 | –3.8 ± 2.0 | –6.1 ± 1.5 | –4.9 ± 2.0 | N.D. | |||||
Norepinephrine metabolites | ||||||||||||
Normethanephrine | 5 | 0.8 ± 1.3 | N.D. | 13.2 ± 3.4 | N.D. | 47.5 ± 5.1 | 67.7 ± 5.8 | |||||
Capsaicin + mormethanephrine | 5 | –4.1 ± 2.6 | N.D. | 10.1 ± 0.8 | N.D. | 45.6 ± 3.4 | 74.1 ± 2.8 | |||||
3,4-Dihydroxymandelic acid | 3 | –0.5 ± 2.4 | –1.9 ± 2.4 | 2.1 ± 8.7 | –2.0 ± 5.0 | 3.7 ± 2.5 | N.D. | |||||
Vanillylmandelic acid | 3 | 1.6 ± 2.4 | –8.4 ± 1.8 | –6.1 ± 4.4 | –6.3 ± 3.3 | –13.0 ± 5.3 | N.D. |
n, number of animals; N.D., not determined