Dose effects of different dopamine uptake inhibitors alone or in combination with cocaine on extracellular dopamine concentrations in the nucleus accumbens shell in mice For drug combinations the ED50 value is that for the cocaine dose when cocaine was administered with the specified dose of the combined drug.
Treatment | ED50 Value | Potency Relative to Cocaine |
|---|---|---|
| mg/kg | ||
| Cocaine | 14.3 (11.6–17.1) | |
| WIN 35,428 | 1.50 (1.08–2.06) | 10.3 (7.46–14.2) |
| WIN 35,428 and cocaine (0.3 mg/kg) | 11.3 (8.15–3.9) | 0.644a (0.472–0.856) |
| WIN 35,428 and cocaine (1.0 mg/kg) | 6.78 (2.79–9.81) | 0.386a (0.264–0.532) |
| JHW 007 at 240 min | 2.81 (1.08–4.74) | 1.87 (1.23–2.72) |
| JHW 007 and cocaine (240 min) (3.0 mg/kg) | 7.64 (0.201–13.0) | 1.00 (0.708–1.42) |
| JHW 007 and cocaine (240 min) (10.0 mg/kg) | 9.57 (1.63–15.0) | 0.597a (0.386–0.859) |
| JHW 007 at 10 min | 3.55 (1.48–6.52) | 0.720 (0.397–1.14) |
| JHW 007 and cocaine (10 min) (3.0 mg/kg) | 10.1 (6.73–13.1) | 1.52 (1.17–1.98) |
| JHW 007 and cocaine (10 min) (10.0 mg/kg) | 12.4 (7.23–16.6) | 1.01a (0.745–1.34) |
↵ a The value is an estimate because there was a significant difference in the mean response (weighted by N) for the two treatments