TABLE 2

Binding affinities of different muscarinic antagonists against the five human muscarinic receptor subtypes The equilibrium dissociation constants of the different muscarinic antagonists were determined in heterologous competition experiments against [³H]NMS. The pK_i values shown are the average of at least three independent experiments performed in triplicate, and the means ± S.E. associated with the measurements were 0.1 or less.