TABLE 1

Effect of trifluoperazine on locomotor ability Mice received trifluoperazine (0.5 mg/kg i.p. or 1.0 mg/kg p.o.) or equal volumes of normal saline (intraperitoneally or by mouth) 4 h before the rotarod test. The duration, up to 300 s, that mice remained on the rotarod revolving at 16 rpm was recorded. Trifluoperazine at the doses and time that showed peak antiallodynic/antihyperalgesic effects did not affect the locomotor activity in mice. Data are expressed in mean ± S.E.M., n = 5 for each group. No statistical differences were identified.