TABLE 1

Liver histology scoring, hepatic triglyceride measurements, and plasma ALT levels of control and ethanol-fed wild-type, Prx6 KO, and Prx6 TG mice Histological scoring data are represented as mean percentage of cells containing lipid vesicles ± S.E.M. in a given zone of a liver lobule when examined at 400× magnification.

Sample	Liver Histology Scoring^a			Triglyceride^b	ALT^c
Sample	Zone 1	Zone 2	Zone 3	Triglyceride^b	ALT^c
WT control	60.3 ± 10.6	63.7 ± 7.9	44.6 ± 4.1	0.076 ± 0.021	22.5 ± 6.5
KO control	37.4 ± 2.4	50.7 ± 3.1	35.1 ± 16.9	0.092 ± 0.037	11.1 ± 8.5
TG control	69.1 ± 9.8^†	72.4 ± 6.6	47.0 ± 2.1	0.129 ± 0.054^*	16.6 ± 5.1
WT ethanol	80.8 ± 1.1^*	94.8 ± 0.6^***	87.4 ± 3.3^***	0.103 ± 0.028	27.5 ± 7.3^*
KO ethanol	56.7 ± 2.3	75.1 ± 1.7	46.4 ± 4.0	0.131 ± 0.015^***^,^†	14.5 ± 2.7
TG ethanol	87.0 ± 2.7^**^,^#^,^%	90.9 ± 3.3^**^,^†^,^‡	79.3 ± 4.4^**^,^‡^,$	0.192 ± 0.018^***^,^‡	29.2 ± 23.4

↵* p < 0.05 (vs. WT control)
↵** p < 0.01 (vs. WT control)
↵*** p < 0.001 (vs. WT control)
↵† p < 0.05 (vs. KO control)
↵# p < 0.001 (vs. KO control)
↵% p < 0.05 (vs. TG control)
↵‡ p < 0.01 (vs. TG control)
↵ a Histology scoring results (see Materials and Methods)
↵ b Hepatic triglycerides (micromoles per milligram of tissue)
↵ c Plasma ALT activity (units per liter)