In vivo occupancy of AR-A000002 and AZD1134 by using [N-methyl-3H3]AZ10419369 ED50 values for AR-A000002 and AZD1134 in vivo occupancy in the guinea pig brain are shown.
| Compounds | ED50 | |||||
|---|---|---|---|---|---|---|
| HT | FC | STR | MID | HPC | OCtx | |
| mg/kg | ||||||
| AR-A000002 | 2.617 | 1.166 | 2.547 | 3.362 | 2.431 | 0.8963 |
| AZD1134 | 0.02580 | 0.01707 | 0.01726 | 0.0230 | 0.01790 | 0.01525 |