IC50 values for CA4 alone or in combination with U0126 in a panel of cell lines
| Cell Line | Cell Type | IC50a | PFb | |
|---|---|---|---|---|
| CA4 | CA4 + U0126 | |||
| nM | ||||
| BEL-7402 | Hepatocellular carcinoma | 3140 ± 890 | 150 ± 50 | 20.9 |
| SMMC-7721 | Hepatocellular carcinoma | 480 ± 30 | 65 ± 9 | 7.4 |
| 3AO | Ovarian cancer | 990 ± 40 | 110 ± 10 | 9.0 |
| KB | Epithelial carcinoma | 37 ± 14 | 10 ± 3 | 3.7 |
| H460 | Non–small-cell lung cancer | 24 ± 6 | 32 ± 1c | 0.8 |
| MDA-MB-231 | Breast cancer | 44 ± 9 | 42 ± 4 | 1.1 |
| SK-BR-3 | Breast cancer | 4.8 ± 0.1 | 3.8 ± 0.5 | 1.3 |
| HCT 116 | Colon cancer | 24 ± 2 | 25 ± 3c | 1.0 |
| DLD-1 | Colon adenocarcinoma | 22 ± 2 | 21 ± 1 | 1.0 |
| SGC-7901 | Gastric cancer | 6.4 ± 0.2 | 5.6 ± 0.3 | 1.1 |
↵ a IC50 values represent the concentrations required to inhibit cell growth by 50%. All SRB data are from at least three independent experiments (mean ± S.E.)
↵ b Potentiation factor (PF50) = IC50(CA4)/IC50(CA4 + U0126). The concentration of U0126 used was 10 μM
↵ c The concentration of U0126 used was 2 μM