Selectivity of polyphenols for human CB1 and CB2 receptors
| Drug | Ki | Selectivity | |||
|---|---|---|---|---|---|
| mCB1 | hCB1 | hCB2 | hCB2/hCB1 | ||
| nM | |||||
| WIN-55,212-2 | 3.4 ± 1.6 (5) | 7.7 ± 1.3 (5) | 5.8 ± 1.2 (4) | 0.75 | Nonselective |
| Curcumin | 73.1 ± 23.5 (7) | 5.9 ± 2.1 (6) | 2600 ± 900 (4) | 446 | CB1 |
| ASC-J9 | 190 ± 110 (8) | 64 ± 17 (3) | 13,000 ± 1300 (4) | 201 | CB1 |
| trans-Resveratrol | 270 ± 160 (6) | 45 ± 17 (3) | >100,000 (4) | >2227 | CB1 |