Brain Region and Compounds | Dose | AUC ± S.E.M. |
---|---|---|
mg/kg | ||
Nucleus accumbens | ||
Bicifadine | 0 | 160 ± 86 |
5 | 6700 ± 1400 | |
10 | 6900 ± 980 | |
20 | 11,000 ± 1500 | |
40 | 19,000 ± 2400* | |
60 | 28,000 ± 6100** | |
Bupropion | 0 | 150 ± 85 |
10 | 9500 ± 1800 | |
30 | 32,000 ± 5000* | |
100 | 84,000 ± 16,000** | |
Amphetamine | 0 | 150 ± 85 |
1 | 18,000 ± 4100 | |
3 | 78,000 ± 15,000** | |
6 | 110,000 ± 9700** | |
Striatum | ||
Bicifadine | 0 | 1000 ± 370 |
5 | 7800 ± 1900 | |
10 | 11,000 ± 1500 | |
20 | 15,000 ± 2100* | |
40 | 28,000 ± 2100** | |
60 | 42,000 ± 4300** | |
Bupropion | 0 | 1100 ± 300 |
10 | 3000 ± 650 | |
30 | 13,000 ± 1500* | |
100 | 51,000 ± 7200** | |
Amphetamine | 0 | 1100 ± 300 |
1 | 28,000 ± 4300* | |
3 | 57,000 ± 8700** |