Potency of bicifadine and reference stimulants/monoamine transport inhibitors in the rat discrimination procedure Values represent the ED50 and 95% confidence interval of a drug in either substituting for the cocaine training dose (Stimulus Effects) or in decreasing the rates of responding relative to saline control test sessions (Response Rate Effects). Values derived from curves fitted to data points by using nonlinear regression analysis (Prism; GraphPad Software, San Diego, CA).
| Drug | Stimulus Effects | Response Rate Effects | Ratio of ED50 values |
|---|---|---|---|
| mg/kg | |||
| Cocaine | 3.6 (3.0–4.4) | >17 | >4.7 |
| Bicifadine | 5.6 (4.6–6.9) | 5.2 (4.8–6.0) | 0.9 |
| d-Amphetamine | 0.4 (0.2–0.7) | 2.9 (2.3–3.6) | 7.2 |
| Bupropion | 16.5 (14.1–19.4) | 36.8 (31.3–43.2) | 2.2 |
| Desipramine | 7.3 (3.4–15.4) | 13.8 (9.5–20.2) | 1.9 |