Average number of arm crosses in the KN93 plus maze assessment Nicotine-withdrawn mice were treated with vehicle, KN93, or the inactive analog KN92, and the total number of crosses between open and closed arms of the plus-maze test was counted. Numbers are presented as the total average number of arm crosses ± S.E.M. for eight mice per group.
| Treatment Group | Average Number of Arm Crosses |
|---|---|
| Saline MP- vehicle | 2.4 ± 0.3 |
| Saline, MP- KN93, 0.01 μg | 2.5 ± 0.6 |
| Nicotine MP- vehicle | 2 ± 0.5 |
| Nicotine MP- KN93, 0.0025 μg | 2.2 ± 0.6 |
| Nicotine MP- KN93, 0.005 μg | 2 ± 0.6 |
| Nicotine MP- KN93, 0.01 μg | 2 ± 0.3 |
| Nicotine MP- KN92, 0.01 μg | 2.2 ± 0.4 |
MP, minipump