TABLE 3

Pharmacokinetic parameters of liposome encapsulated oxymorphone HCl 2 mg/kg s.c. to healthy rhesus monkeys Group 1 (n = 8) was sampled out to 144 h and group 2 (n = 2) was sampled out to 456 h.

Parameter Units Geometric Mean Group 1 Animals Group 2 Animals
AQ96 AS79 AT13 AT48 AW57 AX61 AY60 AZ36 AP88 AQ74
AUCextrapolated % 48.49 45.77 37.12 61.05 54.01 28.43 75.83 50.35 50.22 10.86 2.74
AUC0-last h · ng · ml–1 201.81 98.11 299.78 215.08 124.36 178.74 228.46 566.97 151.04 210.94 231.85
AUC0-inf h · ng · ml–1 424.45 180.90 476.74 552.25 270.43 249.73 945.32 1141.88 303.42 236.63 238.37
AUMC0-inf h · h · ng · ml–1 81,317.40 33,889.23 64,545.36 116,387.11 51,381.27 26,943.43 440,437.75 195,577.93 62,975.84 47,242.81 60,150.91
AUMC0-last h · h · ng · ml–1 13,277.31 5041.46 20,275.01 15,923.12 6431.20 12,045.47 16,031.44 45,242.59 10,560.89 43,886.70 45,786.29
Cl · F–1 ml · min–1 69.89 164.00 62.23 53.72 109.70 118.80 31.38 25.98 97.77 124.46 125.37
C max ng · ml–1 12.78 19.35 20.30 5.26 11.89 14.16 12.70 20.41 7.90 9.17 12.32
MRT0-inf h 191.58 187.34 135.39 210.75 190.00 107.89 465.91 171.28 207.55 198.19 254.20
MRT0-last h 65.79 51.39 67.63 74.03 51.71 67.39 70.17 79.80 69.92 189.29 217.06
T max h 0.57 0.25 0.50 1.00 1.00 1.50 1.00 0.25 0.25 0.50 0.50
Vz · F–1 liters · kg–1 672.03 2011.52 396.36 496.24 1235.75 469.40 843.63 183.16 1173.12 438.63 776.07