Parameter | Units | Geometric Mean | Animal | ||||
---|---|---|---|---|---|---|---|
AO61 | AS26 | AS31 | AX59 | AX63 | |||
AUCextrapolated | % | 0.52 | 0.21 | 0.61 | 0.76 | 0.63 | 1.97 |
AUC0-last | h · ng · ml–1 | 62.26 | 111.41 | 31.56 | 56.62 | 36.67 | 127.22 |
AUC0-inf | h · ng · ml–1 | 62.75 | 111.65 | 31.75 | 57.05 | 36.90 | 129.78 |
AUMC0-inf | h · h · ng · ml–1 | 76.80 | 67.65 | 28.90 | 98.17 | 33.33 | 393.96 |
AUMC0-last | h · h · ng · ml–1 | 69.50 | 64.02 | 26.85 | 91.91 | 30.88 | 308.30 |
C0 | ng · ml–1 | 68.38 | 245.10 | 36.95 | 42.72 | 43.37 | 89.07 |
Cl | ml · min–1 · kg–1 | 23.64 | 13.29 | 46.72 | 26.00 | 40.20 | 11.43 |
t1/2 λz | h | 2.51 | 2.15 | 1.77 | 1.70 | 1.78 | 6.57 |
λz | h–1 | 0.28 | 0.32 | 0.39 | 0.41 | 0.39 | 0.11 |
MRT0-inf | h | 1.22 | 0.61 | 0.91 | 1.72 | 0.90 | 3.04 |
MRT0-last | h | 1.12 | 0.57 | 0.85 | 1.62 | 0.84 | 2.42 |
Vss | liters · kg–1 | 1.74 | 0.48 | 2.55 | 2.68 | 2.18 | 2.08 |
Vz | liters · kg–1 | 5.13 | 2.48 | 7.15 | 3.82 | 6.20 | 6.50 |