TABLE 2

Pharmacokinetic parameters of oxymorphone HCl 0.1 mg/kg i.v. to healthy rhesus monkeys (n = 5)

Parameter Units Geometric Mean Animal
AO61 AS26 AS31 AX59 AX63
AUCextrapolated % 0.52 0.21 0.61 0.76 0.63 1.97
AUC0-last h · ng · ml–1 62.26 111.41 31.56 56.62 36.67 127.22
AUC0-inf h · ng · ml–1 62.75 111.65 31.75 57.05 36.90 129.78
AUMC0-inf h · h · ng · ml–1 76.80 67.65 28.90 98.17 33.33 393.96
AUMC0-last h · h · ng · ml–1 69.50 64.02 26.85 91.91 30.88 308.30
C0 ng · ml–1 68.38 245.10 36.95 42.72 43.37 89.07
Cl ml · min–1 · kg–1 23.64 13.29 46.72 26.00 40.20 11.43
t1/2 λz h 2.51 2.15 1.77 1.70 1.78 6.57
λz h–1 0.28 0.32 0.39 0.41 0.39 0.11
MRT0-inf h 1.22 0.61 0.91 1.72 0.90 3.04
MRT0-last h 1.12 0.57 0.85 1.62 0.84 2.42
Vss liters · kg–1 1.74 0.48 2.55 2.68 2.18 2.08
Vz liters · kg–1 5.13 2.48 7.15 3.82 6.20 6.50