Effect of direct injection of eCG into fetuses on TCDD-induced changes in the weights of body and reproductive organs, and in anogenital and urethrovaginal distances Each value represents the mean ± S.D. of 13 to 18 fetuses removed from three to four dams.
Parameter | Dam... | Control | TCDD | ||
|---|---|---|---|---|---|
| Fetus... | PBS | PBS | eCG | ||
| Male pups | (n = 18) | (n = 16) | (n = 15) | ||
| Body wt (g) | |||||
| PND21 | 54.3 ± 8.8 | 45.8 ± 10.6c | 49.9 ± 7.7 | ||
| PND56 | 285 ± 30 | 258 ± 20c | 271 ± 27 | ||
| PND70 | 338 ± 30 | 323 ± 25 | 328 ± 27 | ||
| PND91 | 392 ± 21 | 377 ± 36 | 386 ± 37 | ||
| PND98 | 424 ± 28 | 402 ± 41 | 411 ± 49 | ||
| Tissue wt (%)a | |||||
| Testis | 0.85 ± 0.07 | 0.83 ± 0.07 | 0.74 ± 0.13c | ||
| Epididymis | 0.15 ± 0.01 | 0.15 ± 0.01 | 0.14 ± 0.02 | ||
| Seminal vesicle | 0.29 ± 0.05 | 0.28 ± 0.05 | 0.30 ± 0.06 | ||
| Ventral prostate | 0.33 ± 0.06 | 0.29 ± 0.05c | 0.30 ± 0.05 | ||
| AGD (%)b | |||||
| PND56 | 0.15 ± 0.02 | 0.14 ± 0.01 | 0.15 ± 0.01 | ||
| PND70 | 0.12 ± 0.01 | 0.12 ± 0.01 | 0.13 ± 0.01 | ||
| PND91 | 0.11 ± 0.01 | 0.11 ± 0.01 | 0.11 ± 0.01 | ||
| Female pups | (n = 13) | (n = 17) | (n = 15) | ||
| Body wt (g) | |||||
| PND21 | 50.0 ± 8.3 | 42.6 ± 3.6c | 51.2 ± 6.8 | ||
| PND49 | 171 ± 20 | 157 ± 12c | 170 ± 13 | ||
| PND70 | 225 ± 19 | 214 ± 15 | 219 ± 17 | ||
| PND91 | 251 ± 22 | 241 ± 18 | 251 ± 19 | ||
| PND98 | 265 ± 20 | 250 ± 22 | 265 ± 20 | ||
| Tissue wt (%)a | |||||
| Ovary | 0.04 ± 0.00 | 0.03 ± 0.00c | 0.03 ± 0.00 | ||
| AGD (%)b | |||||
| PND49 | 0.11 ± 0.01 | 0.10 ± 0.00c | 0.11 ± 0.01 | ||
| PND70 | 0.09 ± 0.01 | 0.09 ± 0.01 | 0.09 ± 0.01 | ||
| PND91 | 0.08 ± 0.01 | 0.08 ± 0.01 | 0.08 ± 0.01 | ||
| UVD (%)b | |||||
| PND49 | 0.03 ± 0.00 | 0.02 ± 0.00c | 0.02 ± 0.00c | ||
| PND70 | 0.02 ± 0.00 | 0.01 ± 0.00c | 0.02 ± 0.00 | ||
| PND91 |
| 0.02 ± 0.00 | 0.01 ± 0.00c | 0.01 ± 0.00c | |