TABLE 1

Hemodynamics Values are mean ± S.E.M.; n, number of rabbits.

Groups
n
Heart Rate
Mean Arterial Pressure
Baseline
CAO 5′
CAO 18′
CAR 10′
Baseline
CAO 5′
CAO 18′
CAR 10′
beats/min mm Hg
Protocol A Control 9 268 ± 11 267 ± 11 255 ± 9 250 ± 10 81 ± 6 75 ± 7 59 ± 3 62 ± 5
17β-E100 6 228 ± 12 222 ± 12 224 ± 7 225 ± 10 73 ± 5 67 ± 8 66 ± 5 68 ± 7
Geni100 6 226 ± 18 219 ± 22 221 ± 17 223 ± 15 72 ± 6 56 ± 13 53 ± 5 71 ± 11
Geni1000 6 252 ± 12 259 ± 10 239 ± 25 251 ± 15 74 ± 3 76 ± 3 80 ± 9 73 ± 5
Protocol D 5-HD 5 258 ± 10 247 ± 11 247 ± 9 228 ± 5 74 ± 10 65 ± 7 65 ± 10 68 ± 10
5-HD + 17β-E100 5 257 ± 26 257 ± 18 241 ± 25 227 ± 10 72 ± 6 63 ± 6 60 ± 6 60 ± 4
5-HD + Geni100 4 248 ± 17 247 ± 13 245 ± 15 245 ± 28 73 ± 7 67 ± 8 69 ± 9 63 ± 6
Protocol B Control 12 248 ± 8 249 ± 10 238 ± 9 239 ± 6 72 ± 5 69 ± 7 69 ± 5 68 ± 4
17β-E100 6 245 ± 13 254 ± 13 245 ± 9 233 ± 9 67 ± 4 63 ± 5 59 ± 5 62 ± 8
Geni100 6 257 ± 6 257 ± 8 241 ± 7 230 ± 6 79 ± 8 67 ± 15 78 ± 13 67 ± 7
Geni1000 6 250 ± 10 251 ± 9 244 ± 8 243 ± 8 69 ± 7 61 ± 4 67 ± 6 65 ± 7
Protocol C SB 216763 6 213 ± 14 223 ± 12 234 ± 10 230 ± 7 69 ± 9 55 ± 7 57 ± 9 61 ± 8
17β-E100 + SB 216763 6 248 ± 13 252 ± 14 249 ± 17 242 ± 10 74 ± 8 60 ± 6 63 ± 5 55 ± 7
Geni100 + SB 216763 6 246 ± 5 241 ± 9 237 ± 26 235 ± 21 82 ± 7 58 ± 9 66 ± 11 60 ± 4
Protocol E 5-HD 6 260 ± 13 270 ± 11 263 ± 17 252 ± 18 65 ± 5 58 ± 5 59 ± 4 61 ± 3
5-HD + SB 216763 + 17β-E100 5 258 ± 13 261 ± 14 249 ± 14 239 ± 17 70 ± 8 59 ± 3 58 ± 3 61 ± 5
5-HD + SB 216763 + Geni100
5
269 ± 11
257 ± 5
253 ± 6
242 ± 8
62 ± 2
55 ± 2
64 ± 8
61 ± 4

  • CAO 18′, 18th min of CAO; CAO 28′, 28th min of CAO; CAR 10′, 10th min of CAR; 17β-E100, intravenous administration of 100 μg/kg 17β-estradiol during the last 5 min of CAO; Geni100, intravenous administration of 100 μg/kg genistein during the last 5 min of CAO; Gen1000, intravenous administration of 1000 μg/kg genistein during the last 5 min of CAO; SB 216763, intravenous administration of 0.2 mg/kg SB 216763 6 min before the onset of CAR; Geni100 + SB 216763, administration of Geni100 and SB 216763; 17β-E100 + SB 216763, administration of 17β-E100 and SB 216763; 5-HD, intravenous administration of 5-hydroxydecanoate at 5 mg/kg 5 min before CAO